EDTA Chelation Therapy: Ankle/Brachial Doppler Systolic Blood Pressure Ratio

Effect of EDTA Chelation Therapy Plus
Multi-vitamin/Trace Mineral Supplementation Upon Vascular Dynamics: Ankle/Brachial Doppler Systolic Blood Pressure Ratio

E.W. McDonagh, DO, C.J. Rudolph, DO, and E. Cheraskin, MD, DMD

Dr. E.W. McDonagh is founder of the McDonagh Medical Center in Gladstone, Missouri, where he practices with Dr. C..J. Rudolph. Dr. E. Cheraskin is Professor Emeritus and former Chairman of the Department of Oral Medicine at the University of Alabama.

ABSTRACT: A study of 117 lower extremities in 77 elderly patients with documented occlusive peripheral vascular stenosis, diagnosed by the Doppler systolic ankle/brachial (ankle/arm) blood pressure ratio is reported. This study showed that intravenous ethylene diamine tetraacetic acid (EDTA) chelation therapy with supportive multivitamin/trace mineral supplementation improved arterial blood flow to the legs significantly after approximately 60 days and 26 infusions (P<0.001).

[Note: Blood pressure is normally higher in the ankles than in the arms. An A/B ratio of less than approximately 1.0 is considered abnormal and is an indication of blockage to the flow of blood to the legs]

Effect of EDTA Chelation Therapy with Vitamin/Mineral Supplementation
upon Ankle-Brachial Systolic Pressure

All Patients	Sample Size	Ankle/Brachial Pressure	Mean Percentage Change	Significance of the Difference of the Means
1 initial 2 final	117 117	0.77±0.22 0.94±0.17	+ 22%	t=8.0041 P<0.001*

Lower (poorer) patients, initial A/B ratio less than 0.80
3 initial 4 final	46 46	0.55±0.19 0.71±0.25	+ 29%	t=3.9771 P<0.001*

Higher (better) patients, initial A/B ratio greater than 0.80
5 initial 6 final	71 71	0.91±0.06 1.08±0.17	+ 19%	t=8.9790 P<0.001*

All Patients Sample Size Ankle/Brachial
Pressure Mean Percentage Change Significance of the
Difference of the Means

1 initial
2 final 117
117 0.77±0.22
0.94±0.17
+ 22%
t=8.0041     P<0.001*

Lower (poorer) patients, initial A/B ratio less than 0.80

3 initial
4 final 46
46 0.55±0.19
0.71±0.25
+ 29%
t=3.9771     P<0.001*

Higher (better) patients, initial A/B ratio greater than 0.80

5 initial
6 final 71
71 0.91±0.06
1.08±0.17
+ 19%
t=8.9790     P<0.001*

*statistically significant difference of the means

Journal of Advancement in Medicine Volume 2, Numbers 1/2, Spring/Summer 1989
For the full-text study, go to your nearest medical library or order
The Textbook of EDTA Chelation Therapy.

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